A Misfolding Misfortune

A 5E-compatible adventure about neurodegenerative disease

Written by: Dimitris Boufidis, Freddy S. Purnell, Tammy Ray, David Sidibe, and Amanda N. Weiss

Image created using Canva.com (elements by Sketchify Japan, Aliansi Bobe, Mohamed_hassan, Frost your design, sparklestroke)

Summary of adventure: The party of adventurers have been gathered to the town of Mo’ach, where the patron fey Coimeád, whose presence sustains the land, has become ill. The player characters (PCs) will learn that the disease is neurodegenerative, meaning that it’s causing the fey’s brain cells to die. The PCs must venture into the creature’s brain and destroy the protein plaques that are causing the cells to die, so that the healer mages can restore the creature’s brain and keep their town thriving.

This adventure is designed for level 3 (3-5 characters).

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Download the accompanying science information fact sheet here: